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Nutraceutical Profiling, Bioactive Composition, and Biological Applications of Lepidium sativum L.

Himalayan Environmental Studies and Conservation Organization, Dehradun, 248006 Uttarakhand, India. Facultad de Ciencias de la Salud, Universidad Arturo Prat, Avda. Arturo Prat 2120, Iquique 1110939, Chile. Departamento de Ciencias Básicas, Facultad de Ciencias, Universidad Santo Tomas, Chile. Center of Molecular Biology and Pharmacogenetics, Scientific and Technological Bioresource Nucleus, Universidad de La Frontera, Temuco 4811230, Chile. Department of Life Sciences, Graphic Era Deemed to Be University, Dehradun, 248 002 Uttarakhand, India. Department of Nutrition and Dietetics, Faculty of Pharmacy and Centre for Healthy Living, University of Concepción, 4070386 Concepción, Chile. Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia. Educational Program, Geography, Environment and Service Sector, Abai Kazakh National Pedagogical University, Almaty, Kazakhstan. Biomedical Research Centre, Al-Farabi Kazakh National University, Almaty, Kazakhstan. Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Pharmaceutical Care Department, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia. Department of Biology, Faculty of Science, Sivas Cumhuriyet University, 58140 Sivas, Turkey. Beekeeping Development Application and Research Center, Sivas Cumhuriyet University, 58140 Sivas, Turkey. Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania. Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong.

Oxidative medicine and cellular longevity. 2022;:2910411
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Abstract

The roots, leaves, and seeds of Lepidium sativum L., popularly known as Garden cress in different regions, have high economic importance; although, the crop is particularly cultivated for the seeds. In traditional medicine, this plant has been reported to possess various biological activities. This review is aimed at providing updated and critical scientific information about the traditional, nutritional, phytochemical, and biological activities of L. sativum. In addition, the geographic distribution is also reviewed. The comprehensive literature search was carried out with the help of different search engines PubMed, Web of Science, and Science Direct. This review highlighted the importance of L. sativum as an edible herb that possesses a wide range of therapeutic properties along with high nutritional values. Preclinical studies (in vitro and in vivo) displayed anticancer, hepatoprotective, antidiabetic, hypoglycemic, antioxidant, antimicrobial, gastrointestinal, and fracture/bone healing activities of L. sativum and support the clinical importance of plant-derived bioactive compounds for the treatment of different diseases. Screening of literature revealed that L. sativum species and their bioactive compounds may be a significant source for new drug compounds and also could be used against malnutrition. Further clinical trials are needed to effectively assess the actual potential of the species and its bioactive compounds.

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Publication Type : Review

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